Manchester City are trading at around 35/1 to win the quadruple, although you can expect these football betting odds to shorten if they manage to overcome Chelsea on Wednesday 9 November. The English champions are strong favourites to reach the last sixteen, with Pep Guardiola likely to field the likes of Jack Grealish, Riyad Mahrez and Phil Foden for this contest.
However, there might not be Erling Haaland or Kevin de Bruyne lining up in a match against a Chelsea side who reached both the EFL Cup and FA Cup final last season. The London outfit are now managed by Graham Potter who will be targeting silverware during his first campaign since recently switching from Brighton.
Betting-wise, it makes sense to look out for team news and bet accordingly. We can see both teams looking to attack in this game and Chelsea might look to field a strong team. Having won at Milan in the Champions League, they certainly have the players to make an impact including Pierre-Emerick Aubameyang, Mason Mount and Raheem Sterling.
Sterling returns to the Etihad Stadium where he won plenty of silverware and perhaps he can be the thorn in the side of the City defence. With Kyle Walker missing for the Cityzens, we could see an open game of football and it could be worth looking at a goals-related bet rather than predicting one team to win.